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Natural Selection 2 official game artwork

THE PRACTICAL GUIDE

Natural Selection 2 Guide

A fast paced multiplayer shooter that pits aliens against humans in a strategic and action-packed struggle for survival!

Steam ↗Windows
GameWiki Pro EditorialReviewed 5 guide topics

GET YOUR BEARINGS

Plan your next Natural Selection 2 session

Our independent guide breaks down Natural Selection 2’s core systems, offering observations that help players understand each role’s impact on the battlefield. By comparing tactics across both sides, you can refine your approach without relying on hidden shortcuts or paid upgrades.

01 / THE GUIDE

Commander Supply Timing

Track how early health‑pack drops affect marine survivability. Compare matches where the Commander prioritizes ammo versus health to see which approach yields higher kill‑death ratios.

  • Watch the Commander’s map markers for emerging objectives.
  • Balance offensive pushes with defensive structures.

02 / THE GUIDE

Alien Hive Placement

Observe enemy movement after a new Hive is built. Note whether expanding infestation near choke points forces humans to adjust their defensive layout.

  • Prioritize resource nodes to keep supply drops steady.
  • Use abilities that match your team’s current composition.
Natural Selection 2 official gameplay screenshot
Publisher-provided gameplay image · Unknown Worlds Entertainment

03 / THE GUIDE

Marine Weapon Matchups

Test shotguns against Skulks in tight corridors versus rifles in open arenas. Record damage output and reload times to gauge optimal engagement distances.

  • Use Skulks for rapid flank attacks.
  • Deploy Gorges to maintain tunnel networks for egg spawning.

04 / THE GUIDE

Exosuit vs. Onos

Pit a marine Exosuit equipped with a railgun against an Onos. Measure how long the Exosuit survives and the damage dealt before the Onos overwhelms it.

  • Carry cluster grenades to counter wall‑running Skulks.
  • Equip jetpacks for quick repositioning when attacking Hives.

05 / THE GUIDE

Mod Impact Evaluation

Install a community map and compare its objective layout to a vanilla map. Assess how map design influences Commander strategies and team coordination.

  • Browse the Steam Workshop for fresh maps and balance changes.
  • Try a simple mod to become familiar with the provided toolset.

WATCH THE GAME

Natural Selection 2 videos

Official trailers & gameplay

INSIDE THE WORLD

Screenshots & game images

5 official screenshots

IN THIS WIKI

Your reading checklist

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QUICK ANSWERS

Natural Selection 2 FAQ

Which operating systems does Natural Selection 2 support?

The game is officially available for Windows; macOS and Linux are not listed as supported platforms.

Does Natural Selection 2 include a level editor?

Yes, the game ships with a level editor and full mod tools for creating custom maps and content.

What multiplayer mode is featured in Natural Selection 2?

The primary mode is online player‑versus‑player, with each side guided by a Commander; no single‑player campaign is mentioned.

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SOURCES & CREDITS

Official resources and further reading

Original editorial guidance. Game imagery and trailers are provided by the publisher through Steam. Media and reference links checked 2026-10-22. Game versions, supported platforms, and balance can change; consult the linked release notes for current details.