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Destroy All Humans! official game artwork

THE PRACTICAL GUIDE

Destroy All Humans! Guide

The cult-classic returns! Terrorize the people of 1950's Earth in the role of the evil alien Crypto-137. Harvest their DNA and bring down the US government in the faithful remake of the legendary alien invasion

Steam ↗Windows
GameWiki Pro EditorialReviewed 5 guide topics

GET YOUR BEARINGS

Plan your next Destroy All Humans! session

Our guide delves deeper into the remake’s core elements, offering observations that help players appreciate the blend of humor, alien tech, and 1950s nostalgia. By comparing each feature, you can tailor your approach to maximize enjoyment without relying on undocumented mechanics.

01 / THE GUIDE

Weapon Variety Comparison

Contrast the Anal Probe Gun’s crowd‑control style with the raw power of psychokinetic throws. Note how each fits different combat scenarios and how switching between them changes enemy reactions.

  • Experiment with the Anal Probe Gun for both crowd control and comedic effect.
  • Combine psychic throws with other weapons to maximize enemy disruption.

02 / THE GUIDE

Traversal Technique Study

Map a route using only the jetpack, then repeat using the saucer. Observe how vertical mobility influences encounter pacing and the discovery of hidden areas.

  • Use the jetpack to scout rooftops before engaging ground targets.
  • Switch to the saucer for a broader view of city layouts.
Destroy All Humans! official gameplay screenshot
Publisher-provided gameplay image · Black Forest Games, Pandemic Studios

03 / THE GUIDE

Psychic Ability Timing

Experiment with the timing of psychokinetic attacks on moving targets. Record how delay affects hit accuracy and whether environmental objects enhance damage.

  • Target groups of enemies with psychokinesis for efficient crowd control.
  • Use objects in the environment as improvised projectiles.

04 / THE GUIDE

Lost Mission Narrative Impact

Play through the Lost Mission of Area 42 and compare its storyline beats to the main campaign. Identify any new themes or character moments introduced.

  • Approach the Lost Mission as a continuation of the main story for narrative cohesion.
  • Take note of new enemy placements unique to Area 42.

05 / THE GUIDE

Platform Feature Utilization

Test Steam Cloud synchronization across multiple devices and assess remote play performance on a tablet. Evaluate how these services affect session continuity and convenience.

  • Enable Steam Cloud to keep your progress synchronized.
  • Use remote play on a tablet for flexible gaming locations.

WATCH THE GAME

Destroy All Humans! videos

Official trailers & gameplay

INSIDE THE WORLD

Screenshots & game images

5 official screenshots

IN THIS WIKI

Your reading checklist

0 of 6 complete

QUICK ANSWERS

Destroy All Humans! FAQ

What era does the game’s setting portray?

The game is set in 1950s America, featuring cities and cultural elements from that decade.

Is the game single‑player only?

The listed features indicate a single‑player experience.

Can I play using a controller on Windows?

Full controller support is provided for the Windows version, allowing gameplay with a gamepad.

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SOURCES & CREDITS

Official resources and further reading

Original editorial guidance. Game imagery and trailers are provided by the publisher through Steam. Media and reference links checked 2026-10-24. Game versions, supported platforms, and balance can change; consult the linked release notes for current details.